Hypertensive emergency vs urgency (asymptomatic severe)
Separates a hypertensive emergency from hypertensive urgency, which is the same thing as asymptomatic severe hypertension (ESC: severe hypertension without acute HMOD; AHA/ACC 2025: severe hypertension without acute target-organ damage). Enter the BP and mark the acute hypertension-mediated organ damage screen: fundoscopy, neurological examination, ECG and troponin, creatinine and urinalysis, LDH, haptoglobin, platelets and blood film for thrombotic microangiopathy, chest X-ray, echocardiography, aortic imaging and, in pregnancy, the pre-eclampsia screen. Acute organ damage means IV therapy in intensive care; without it, BP is lowered gradually with oral drugs as an outpatient, because rapid or IV lowering of asymptomatic severe BP adds harm without benefit. ESC 2024 and ACC/AHA definitions are shown side by side, with the obstetric threshold of 160/110, a definition of malignant hypertension (severe BP with advanced bilateral retinopathy, often with TMA or AKI), and a medication check: no ACE inhibitor such as captopril on sacubitril/valsartan, and no nitrates after a PDE5 inhibitor, including tadalafil 5 mg daily for the prostate.
- Often with thrombotic microangiopathy (haemolysis, schistocytes, low platelets, LDH ↑, haptoglobin ↓), acute kidney injury with proteinuria or haematuria, encephalopathy or acute heart failure.
- With multi-organ damage: retinopathy plus damage to ≥ 2 of kidney, heart and brain, or TMA. Worst prognosis.
- Papilloedema is no longer needed: the older split into accelerated (grade III: haemorrhages and exudates) and malignant (grade IV: papilloedema) hypertension has been dropped because prognosis is the same.
- Untreated 1-year mortality was about 80%; it is still a hypertensive emergency, even when the patient feels well. Secondary causes (renovascular, primary aldosteronism, phaeochromocytoma, kidney disease) are common.
- Treatment: admit, IV labetalol or nicardipine and lower MAP by 20–25% over several hours (not minutes); then a low-dose oral RAS blocker (high renin), carefully, because patients are often volume-depleted.
- Malignant hypertension: severe BP elevation with fundoscopic changes (flame haemorrhages and/or papilloedema), microangiopathy and disseminated intravascular coagulation; can come with encephalopathy, acute heart failure and acute kidney deteriorationESC 2024 · ESC 2019
- Target: reduce MAP by 20–25% over several hours; labetalol or nicardipine, alternatives nitroprusside or urapidilESC 2024
- Not a separate category: one form of hypertensive emergency (> 180/120 with new or worsening target-organ damage)ACC/AHA 2017
- Reduce SBP by ≤ 25% in the first hour, then to 160/100–110 over 2–6 h, then to normal over 24–48 hIACC/AHA 2017
- McEvoy JW, et al. 2024 ESC Guidelines for the management of elevated blood pressure and hypertension. Eur Heart J 2024;45:3912-4018.
- van den Born BJH, Lip GYH, et al. ESC Council on hypertension position document on the management of hypertensive emergencies. Eur Heart J Cardiovasc Pharmacother 2019;5:37-46.
- Whelton PK, Carey RM, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the prevention, detection, evaluation, and management of high blood pressure in adults. Hypertension 2018;71:e13-e115.
- 2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the prevention, detection, evaluation and management of high blood pressure in adults. Circulation 2025.
- Bress AP, Anderson TS, et al. The management of elevated blood pressure in the acute care setting: a scientific statement from the American Heart Association. Hypertension 2024;81:e94-e106.
- American College of Obstetricians and Gynecologists. Clinical management guidelines: Emergent therapy for acute-onset, severe hypertension during pregnancy and the postpartum period. ACOG Committee Opinion No. 767. Obstet Gynecol 2019;133:e174-e180.
- Magee LA, Brown MA, et al. The 2021 International Society for the Study of Hypertension in Pregnancy classification, diagnosis & management recommendations for international practice. Pregnancy Hypertens 2022;27:148-169.
- Cremer A, Amraoui F, Lip GYH, et al. From malignant hypertension to hypertension-MOD: a modern definition for an old but still dangerous emergency. J Hum Hypertens 2016;30:463-466.
- Lip GYH, Beevers M, Beevers DG. Complications and survival of 315 patients with malignant-phase hypertension. J Hypertens 1995;13:915-924.
- Heidenreich PA, et al. 2022 AHA/ACC/HFSA Guideline for the management of heart failure. Circulation 2022;145:e895-e1032 (ARNI: no ACE inhibitor within 36 h).