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Hypertensive emergencies

Hypertensive emergency vs urgency (asymptomatic severe)

Separates a hypertensive emergency from hypertensive urgency, which is the same thing as asymptomatic severe hypertension (ESC: severe hypertension without acute HMOD; AHA/ACC 2025: severe hypertension without acute target-organ damage). Enter the BP and mark the acute hypertension-mediated organ damage screen: fundoscopy, neurological examination, ECG and troponin, creatinine and urinalysis, LDH, haptoglobin, platelets and blood film for thrombotic microangiopathy, chest X-ray, echocardiography, aortic imaging and, in pregnancy, the pre-eclampsia screen. Acute organ damage means IV therapy in intensive care; without it, BP is lowered gradually with oral drugs as an outpatient, because rapid or IV lowering of asymptomatic severe BP adds harm without benefit. ESC 2024 and ACC/AHA definitions are shown side by side, with the obstetric threshold of 160/110, a definition of malignant hypertension (severe BP with advanced bilateral retinopathy, often with TMA or AKI), and a medication check: no ACE inhibitor such as captopril on sacubitril/valsartan, and no nitrates after a PDE5 inhibitor, including tadalafil 5 mg daily for the prostate.

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Blood pressure
Repeat after 30 min of rest before labelling
Acute hypertension-mediated organ damage (HMOD)
Mark each test; core tests are needed before calling it urgency
Fundoscopycore
Flame haemorrhages, cotton-wool spots or papilloedema (malignant hypertension)
Neurological examination ± CT/MRIcore
Encephalopathy (headache with confusion, seizures, visual loss), stroke or PRES
ECG and hs-troponincore
New ischaemia or a troponin rise (acute coronary syndrome)
Creatinine, electrolytes and urinalysiscore
Acute kidney injury, new proteinuria or haematuria
Hypokalaemia raises suspicion of primary aldosteronism (aldosterone/renin ratio)
Hb, platelets, LDH, haptoglobin, blood filmcore
Haemolysis (LDH ↑, haptoglobin ↓, schistocytes) with thrombocytopenia: thrombotic microangiopathy
Chest X-ray
Acute pulmonary oedema
Echocardiography
New LV dysfunction, wall-motion abnormality or a dissection flap (LVH alone is chronic damage)
CT angiography of the aorta (if suspected)
Acute aortic syndrome
Revise the patient's medications
Ask before giving any drug in the ER
Emergency vs urgency (asymptomatic severe)
Enter the BP, then mark the organ-damage tests.
Malignant hypertension = ?
A hypertensive emergency defined by the retina, with small-artery fibrinoid necrosis in the kidney and other organs
Severe BP (grade 3, usually > 200/120 mmHg) + advanced bilateral hypertensive retinopathy: flame-shaped haemorrhages, cotton-wool spots and/or papilloedema (Keith–Wagener–Barker grade III–IV).
  • Often with thrombotic microangiopathy (haemolysis, schistocytes, low platelets, LDH ↑, haptoglobin ↓), acute kidney injury with proteinuria or haematuria, encephalopathy or acute heart failure.
  • With multi-organ damage: retinopathy plus damage to ≥ 2 of kidney, heart and brain, or TMA. Worst prognosis.
  • Papilloedema is no longer needed: the older split into accelerated (grade III: haemorrhages and exudates) and malignant (grade IV: papilloedema) hypertension has been dropped because prognosis is the same.
  • Untreated 1-year mortality was about 80%; it is still a hypertensive emergency, even when the patient feels well. Secondary causes (renovascular, primary aldosteronism, phaeochromocytoma, kidney disease) are common.
  • Treatment: admit, IV labetalol or nicardipine and lower MAP by 20–25% over several hours (not minutes); then a low-dose oral RAS blocker (high renin), carefully, because patients are often volume-depleted.
Definitions
ESC
  • Malignant hypertension: severe BP elevation with fundoscopic changes (flame haemorrhages and/or papilloedema), microangiopathy and disseminated intravascular coagulation; can come with encephalopathy, acute heart failure and acute kidney deterioration
    ESC 2024 · ESC 2019
  • Target: reduce MAP by 20–25% over several hours; labetalol or nicardipine, alternatives nitroprusside or urapidil
    ESC 2024
ACC/AHA
  • Not a separate category: one form of hypertensive emergency (> 180/120 with new or worsening target-organ damage)
    ACC/AHA 2017
  • Reduce SBP by ≤ 25% in the first hour, then to 160/100–110 over 2–6 h, then to normal over 24–48 h
    IACC/AHA 2017
References
  1. McEvoy JW, et al. 2024 ESC Guidelines for the management of elevated blood pressure and hypertension. Eur Heart J 2024;45:3912-4018.
  2. van den Born BJH, Lip GYH, et al. ESC Council on hypertension position document on the management of hypertensive emergencies. Eur Heart J Cardiovasc Pharmacother 2019;5:37-46.
  3. Whelton PK, Carey RM, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the prevention, detection, evaluation, and management of high blood pressure in adults. Hypertension 2018;71:e13-e115.
  4. 2025 AHA/ACC/AANP/AAPA/ABC/ACCP/ACPM/AGS/AMA/ASPC/NMA/PCNA/SGIM Guideline for the prevention, detection, evaluation and management of high blood pressure in adults. Circulation 2025.
  5. Bress AP, Anderson TS, et al. The management of elevated blood pressure in the acute care setting: a scientific statement from the American Heart Association. Hypertension 2024;81:e94-e106.
  6. American College of Obstetricians and Gynecologists. Clinical management guidelines: Emergent therapy for acute-onset, severe hypertension during pregnancy and the postpartum period. ACOG Committee Opinion No. 767. Obstet Gynecol 2019;133:e174-e180.
  7. Magee LA, Brown MA, et al. The 2021 International Society for the Study of Hypertension in Pregnancy classification, diagnosis & management recommendations for international practice. Pregnancy Hypertens 2022;27:148-169.
  8. Cremer A, Amraoui F, Lip GYH, et al. From malignant hypertension to hypertension-MOD: a modern definition for an old but still dangerous emergency. J Hum Hypertens 2016;30:463-466.
  9. Lip GYH, Beevers M, Beevers DG. Complications and survival of 315 patients with malignant-phase hypertension. J Hypertens 1995;13:915-924.
  10. Heidenreich PA, et al. 2022 AHA/ACC/HFSA Guideline for the management of heart failure. Circulation 2022;145:e895-e1032 (ARNI: no ACE inhibitor within 36 h).
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